New Build for Virtualization and General Purpose

[lgfamily]

Approximate Purchase Date: This month
Budget Range: $2000-$4000
System Usage from Most to Least Important: Running 2-3 virtual machines, email, browsing, streaming. No gaming.
Are you buying a monitor: Yes, at least two.
Parts to Upgrade: CPU, mobo, Ram, SSD, fans, heatsink, psu, video, etc
Do you need to buy OS: No, Linux Mint, one of virtuals will have Win7Pro
Preferred Website(s) for Parts: Newegg
Overclocking: No
SLI or Crossfire: No
Your Monitor Resolution: haven't decided yet
Additional Comments: Computer is used mainly for work (healthcare industry).

And Most Importantly, Why Are You Upgrading: well the computer I am currently using I built back in 2009. (High end parts at the time.) I figured it was time for an upgrade

Parts Preferences:
Intel Xeon E5-2640 V4 Broadwell-EP 2.4 GHz 10 x 256KB L2 Cache 25MB L3 Cache LGA 2011-3 90W BX80660E52640V4 Server Processor
https://www.newegg.com/Product/Product.aspx?Item=N82E16819117631

ASRock X99 Taichi LGA 2011-v3 Intel X99 SATA 6Gb/s USB 3.1 USB 3.0 ATX Intel Motherboard
https://www.newegg.com/Product/Product.aspx?Item=N82E16813157719

G.SKILL Ripjaws 4 Series 64GB (8 x 8GB) 288-Pin DDR4 SDRAM DDR4 2133 (PC4 17000) Memory Kit Model F4-2133C15Q2-64GRR
https://www.newegg.com/Product/Product.aspx?Item=N82E16820231834

EVGA GeForce GTX 1080 FTW GAMING ACX 3.0, 08G-P4-6286-KR, 8GB GDDR5X, RGB LED, 10CM FAN, 10 Power Phases, Double BIOS, DX12 OSD Support (PXOC)
https://www.newegg.com/Product/Product.aspx?Item=N82E16814487245

Seasonic PRIME Ultra 1000W 80+ Titanium Power Supply, Full Modular, 135mm FDB Fan w/Hybrid Fan Control, ATX12V & EPS12V, Power On Self Tester, SSR-1000TR
https://www.newegg.com/Product/Product.aspx?item=N82E16817151195

Noctua NH-D14 SE2011 140mm and 120mm SSO CPU Cooler
https://www.newegg.com/Product/Product.aspx?Item=9SIA9PV3Y62105

 

[vapour]

You don't need that powerful GPU for streaming.
X99 is not worth the money anymore, threadripper is better performance for similar cost and platform is new, I recommend heavy load work station:

PCPartPicker part list / Price breakdown by merchant

CPU: AMD - Threadripper 1950X 3.4GHz 16-Core Processor ($949.99 @ Newegg)
CPU Cooler: Enermax - LiqTech TR4 360 102.2 CFM Liquid CPU Cooler ($140.49 @ Newegg)
Motherboard: ASRock - X399 Taichi ATX TR4 Motherboard ($333.98 @ Newegg)
Memory: G.Skill - Ripjaws V Series 64GB (4 x 16GB) DDR4-3200 Memory ($913.99 @ Newegg)
Storage: Samsung - 960 EVO 500GB M.2-2280 Solid State Drive ($239.29 @ Newegg)
Storage: Seagate - Barracuda 2TB 3.5" 7200RPM Internal Hard Drive ($59.99 @ Newegg)
Video Card: PNY - GeForce GTX 1070 8GB Video Card ($549.99 @ Newegg Marketplace)
Case: Fractal Design - Define R6 Black TG ATX Mid Tower Case ($164.98 @ Newegg)
Power Supply: SeaSonic - FOCUS Plus Gold 850W 80+ Gold Certified Fully-Modular ATX Power Supply ($126.98 @ Newegg)
Operating System: Microsoft - Windows 10 Home OEM 64-bit ($112.98 @ Newegg)
Monitor: Lenovo - L24q 23.8" 2560x1440 60Hz Monitor ($216.46 @ Newegg Marketplace)
Monitor: Lenovo - L24q 23.8" 2560x1440 60Hz Monitor ($216.46 @ Newegg Marketplace)
Total: $4025.58
Prices include shipping, taxes, and discounts when available
Generated by PCPartPicker 2018-01-09 16:56 EST-0500

However, if only 3 VMs and streaming, I will get this more than enough build for your purpose:

PCPartPicker part list / Price breakdown by merchant

CPU: AMD - Ryzen 5 1600 3.2GHz 6-Core Processor ($201.98 @ Newegg)
Motherboard: ASRock - AB350 Pro4 ATX AM4 Motherboard ($56.98 @ Newegg)
Memory: G.Skill - Ripjaws V Series 32GB (2 x 16GB) DDR4-3200 Memory ($431.99 @ Newegg)
Storage: Samsung - 960 EVO 250GB M.2-2280 Solid State Drive ($135.99 @ Newegg Marketplace)
Storage: Western Digital - Caviar Blue 1TB 3.5" 7200RPM Internal Hard Drive ($48.99 @ Newegg)
Video Card: Asus - GeForce GTX 1050 Ti 4GB Phoenix Video Card ($152.99 @ Newegg)
Case: Corsair - 200R ATX Mid Tower Case ($39.99 @ Newegg)
Power Supply: Corsair - CXM 550W 80+ Bronze Certified Semi-Modular ATX Power Supply ($34.99 @ Newegg)
Operating System: Microsoft - Windows 10 Home OEM 64-bit ($112.98 @ Newegg)
Monitor: Acer - KN242HYL 23.8" 1920x1080 60Hz Monitor ($99.99 @ Newegg)
Monitor: Acer - KN242HYL 23.8" 1920x1080 60Hz Monitor ($99.99 @ Newegg)
Total: $1416.86
Prices include shipping, taxes, and discounts when available
Generated by PCPartPicker 2018-01-09 16:58 EST-0500