Barring from some strange BIOS configuration, it should be fine. In my experience, it's usually when you take an old board and a new-ish GPU that it might be problematic. A BIOS update fixed it in my case. (FWIW, it was an RX 580 on either H61 or B75 board, can't remember which).
Heck, I've used an HD 4650 as a basic display output when I sold my RX 580 and gotten myself a deal on a secondhand 1080, and the 1080 came a bit late due to shipping. Both the 1080 and the motherboard is what I have in my sig below. Works fine, it's just with that pre-GCN AMD cards you need to jump through a few hoops to get proper display (i.e. not 1024x768).
In short, it should be fine. Just be ready to tinker with driver some since Nvidia seems to be...