There are many niche applications where this is going to be a godsend. I work on very large complex computations, which use humongous swap files (almost 1TB) and massive amounts of RAM. This will provide a huge boost to performance, especially if I put a few drives together (I run 15,000rpm SAS drives now!). I know of people doing quantum mechanical computations on big (real) molecules and to get usable numbers the level of theory needs to be high. For games and entertainment, I might have to give a pass on this one!