With modern GPUs having their own DDR5 RAM in 2 or more GB, system RAM speed isn't that big a deal. Also there's more than just timing, there's latency. The 6,6,6-18 may be just as fast as the 5,5,5-18 if it has lower latency. DDR2 covered many different chipsets with many different RAM controllers. It hard to tell how any one of them will or won't handle 2+2, and 4GB modules mixed. 4x2GB would be better. If you overclock your CPU by raising the FSB then your RAM speed will increase also and that's when you need to worry about how to make it run faster. Usually by slowing it down some 😉