Yes that can, even with the same exact models it can still be problematic, which is why they sell such a wide variety of sets, in each set all sticks are tested to work together, might pull 4 consecutive sticks off an assembly line and it's possible no two will play together (though that's doubtful, but possible, it's also why 4 stick sets cost more then 2 two stick sets, and why the DRAM manufacturers guarantee only the contents of each single package - with that in mind though, take one packaged set, install and enable XMP - then raise the DRAM voltage + 0.06 over spec - if 1.5 sticks make it 1.56, also set the VCCSA voltage to 1.03 and give it a try, if still problems, look in the DRAM advanced timings and let me know what the tRFC timing is at