Not with out replacing the motherboard since it only has one PCI-E x16 slot. GPU's will NOT fit or work in a PCI-E x1 slot. The only way you could do that would be to by a single card dual GPU version like the GTX 690 or HD 7990. But if you go that rout make sure your PSU is of a good quality and adequate wattage/amp's because those kind of cards will pull quite abit from the PSU.