Yes, that's interesting and attractive. It MAY have some technical weaknesses.
1. Plexiglass is not a very good conductor, so it can build up and hold static electric charges that can be a hazard to electronics.
2. Although it is not obvious, all cases - even those made of fiberglass or plastics - have an electrically-conductive coating on their inside. This has two functions: (a) it can carry away (to the Ground lead of the power cable) any static electric charges; and, (b) it acts like a real metallic interior "case" that shields the components from exterior electrical noise signals.