beastyb :
I've tried different mice and different USBs
So does this happen with all mice you try? I f so, it's not the mouse but probably a system file problem or the USB controller needing a driver update.
Go to Computer (This PC in W8 & 10), right click it, click Manage, then Device Manager. In Device Manager look for any colored warning flags of items that do not have drivers.
no m8 everything looks update even try updating the drivers says already using best software