Oh yes i do, ubuntu 9.04 alpha with ext4, running on my OCed setup, boots from post to login in under 5 seconds, and thats on my slower hdd with 16MB cache, my main vista hdd uses 32MB cache. current setup:
c2q q9300 @3.52GHz/1.39V
2x2gb mushkin pc2-6400 @935MHz/2.1V/5-5-5-18
asus p5q-e
assu eah4870 dk top 512 @835gpu/1085mem
wd 750gb black
wd 500gb caviar
lite on 22x dvd burner sata
installing ubuntu, not a single driver was needed, only updated gpu drivers for better performance. even my 1920x1080 lcd was detected properly upon install, and i have since upgraded to a samsung t240 and it works just fine as well. overall its great, the ONLY downside i see is gaming, which is far better on windows. aside from that, WINE lets me use any programs i like from windows, and there are many great open source alternatives to the everyday things i do in windows. plus, vista's and 7's aero has NOTHING on Compiz Fusion. if you dont know what it is, google it, you'll love it, guaranteed.