Manufacturers may put ESD protection, but if you need to touch the interface pins with one hand, grab the computer's bare metal frame with the other hand first (with the plug in the power supply to have a reference to earth). If you are uncomfortable with the power supply plugged, you can turn the switch off behind the fan, the ground wire will still be connected.
I once zapped my sound card input with ESD, it died. As an electrotechnician, I failed to follow the basic preventive steps, by abuse of confidence: "Any self respecting company would put ESD protection on their inputs!" well, no... so I paid the price.