As a rule, you will obtain the best thermal interface between your cpu and heatsink by removing any contaminants from them and mating the surfaces using a small amount of thermal compound. Many people swear by artic silver (II) for this purpose.
www.articsilver.com gives details and installation instructions.
You want the surface of your cpu die and the heatsink to be as flat and clean as possible. The thermal compound helps filling tiny gaps between the two and help heat transfer. The majority of pads seem poor performers.
The pad is often stubborn to remove, especially after you have run your system. A careful razor blade, on its edge, or thumb nail, aided by cotton buds, lint free cloth and rubbing alcohol/nail varnish remover/isopropyl alcohol work best.
Pete
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