I am looking for the answer as well. Computer is seriously infected.
Malwarebytes will run and eliminate things in Safe mode.
Once booted in normal mode the malware returns and will not allow ANY software to run, Imeadiately shuts the openng software.
Superantispyware and Malwarebytes will not allow you to load and scan upon start up without purchasing the software.

Any suggestions would be greatly appreciated.
Thanks,
Shannon