It would work fine with that pair but your bigger issue would be gaming, if that's your main use as SLI/CF drivers support is pretty poor nowadays. Depending on the game you could experience a few different things...
-Better performance then single GPU.
-Same performance then single GPU.
-Worse performance then single GPU.
With the less support your more then likely going to see the last two things most commonly. You'd be better off buying the single better GPU over two weaker ones.