Should work fine. The only compatibility problems I ever had were on SATA 1.5Gb boards where you had to jumper or use a drive manufacturer utility to lock SATA 3Gb drives at 1.5Gb xfer rate to make them work. I don't think any SATA 6Gb drives even have either of those options.
You could use even a 4TB drive as a secondary disk, but you can't boot from >2TB.