I have tried the 500 GB Seagate hybrid drives but not the more recent 750GB model that doubled the flash partition to 16GB. I have heard encouraging things and I think for a single drive solution that requires large capacity with quick than normal SATA access times, it is a winner. Have a catalog designer in the office using one in her laptop she uses for CS5 and she is happy with the performance versus a standard drive. As they continue to increase the density of flash memory, I think we will see higher capacity drives at decreasing prices, but I think that's 2-3 years down the road for the next really significant change. There are some sub $/GB options out there (including the Samsung 830 if you get lucky on some popular sites) so we are in the right direction to make drive manufacturers compete at those price points. As a consumer with a lot of data, I think it's great.
Keep going Seagate, increase the flash partition to 32GB and lets see how fast we can make these things fly!