Yes, but an RX 480 would not give you alot more than 75Fps at 1080p on Ultra. Unless your the type of gamer that mad about CS GO, or something like that where you would want 200fps, a 75Hz screen is more than enough. I own a 75hz FreeSync Monitor, and i have it connected to an RX 480, for latest games, your not going to get huge fps on Ultra settings and 75fps is very good especially with FreeSync.