Ryzen and 300 chipset MBs were a revolution for AMD, anything after that is just evolution so I don't expect any crippling bugs to happen after all these years despite socket. DDR5 and PCIe upgrades, Sure, there will be a rapid series of BIOS upgrades and AMD is releasing own substitute for XMP just because of DDR5 being somewhat unpredictable. Even with DDR4, BIOS in AMD based MBs often had to modify XMP to suit particular setup and IMC.
Zen4 and chipset(s) do not worry meat all but DDR5 and PCIe v6 are nowhere close to maturing enough.