There's no "loss" as it's digital so it either works or it doesn't, although if it doesn't it can sometimes fallback to a slower speed.
If it can operate at USB 2.0 speeds then that's easy as it's definitely good to 16.4' (5 meters) between each active repeater.
The spec for USB 3.0 and 3.1 is 9.8' (3 meters) but I have never had any luck with anything longer than 3' running at full speed. There are active repeaters for these too so I suppose you could place them every 3'.
USB 3.2 and 4.0 have a more realistic 2.6' (0.8 meters) rating between repeaters