I agree with scout_03; sounds like a short.
1) Check that memory is properly seated.
2) Check that PCI cards (GPU) is properly seated.
3) Check for extra standoffs under the motherboard that don't have a corresponding screw hole on the motherboard.
4) Check for anything that 'fell' into the case or is caught behind the motherboard.
5) Check unused ports to make sure they are not damaged and don't have something shoved in them
Is this a new built? or an old build with a new problem?