Checking back nearly a week after publication of this extensive article with evidently plenty of work invested,...
...the huge mass of comments seem to confirm my first impression: this dream is shared by practically no one.
Having a laptop with a swappable core is a dream that has been dreamt again and again, including by Intel with their compute card, two decades ago already. I don't know where a Framework module for a RP5 compute module would land in price, but of course that requires a Framework laptop to start with. And they have started an even more [currently] nonsensible module for a RISC-V, which I am sure is selling like hotcakes...?
(And I am actually quite convinced that both, the RP and the RISC-V chips could be emulated or rather transpiled faster than any 'original', albeit not clock-by-clock)
But the truth is: Raspberries have only two advantages: price and support. They suck everywhere else.
And notebooks are too much about getting work done, preferably with much better performance and longer battery life than any existing or future RP is likely to offer. It's small enough to carry along with a normal notebook and when you really want to tinker with RP specific stuff, you're very likely sitting down close to some socket or a power bank. And then VNC, X11, or just ssh will do well-enough in the mean-time.
IMHO this thing is e-waste in the making and hope a lackluster fundraiser will keep that from happening.