Well I don't know much about vaping but it might hurt it since when you vape it will release a smoke like substance that could lead to condensations and thus liquid on a electronic part. Since you do not have the Radeon 3450 in the case, it would be susceptible to this. However, I don't think there is enough of it to get to that point. So I guess what I am trying to say is that it could go either way, I don't vape and I simply do not know to be honest.