If I remember correctly, I believe:
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If your OS is 32bit:
If the drive is your primary (boot) drive, 2.2TB limit is in place.
If the drive is a secondary drive or external drive, 2.2TB limit is NOT in place.
Reason why is GPT vs MBR. MBR has 2.2TB limit, GPT does NOT have the limit. Problem is 32bit OS doesn't support booting from GPT drives, can only boot from MBR.
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If your OS is 64bit:
AND
If your mobo supports UEFI (yours does NOT),
If the drive is a primary (boot) drive, the 2.2TB limit is NOT in place
If the drive is a secondary/external drive, the 2.2TB limit is NOT in place
Reason why again is the GPT vs MBR, with the UEFI issue tossed in for good measure.
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It's all rather confusing, but it does boil down to legacy design. MBR (legacy) partition schemes were designed for a hard limit of 2.2TB and a maximum of 4 partitions, while the newer GPT format allows for much more size and many more partitions. Meanwhile, most operating systems do support GPT partitioned disks, but because of a combination of underlying legacy hardware (which people are reluctant to repleace) it can become a bit of a mess. Add in the 'bitness' of the OS, and it can become problematic when upgrading hardware piecemeal.
A great example of this is my main rig which complements my media server as a backup. I have the media server (CentOS, RAID5, 5x2TB drives) and it's backed up to my main rig which runs another VM (CentOS, RAID5, 3x4TB). The Media server uses 2TB drives no problem. Meanwhile, my rig (Asus P7F7-E WS, Xeon X3470) gets the 4TB drives plugged in, detects the full 4TB in BIOS, but under Windows (64bit) only sees 700MB drives. So, I plug in a simple PCIe -> 4 port SATA adapter, and all 3 drives show up with the full 4TB visible.
Weird huh?
Overall, considering the age of your motherboard, I am pretty sure it doesn't support EFI/UEFI. So - using a large HDD as your PRIMARY boot drive probably is not going to work. Using it as a secondary storage drive or in an external drive SHOULD work as long as you're using an OS newer than Win XP.