Having high disk usage might sometimes be something to do with windows, such as prefetching data, making searches faster, and loading new content on live tiles.
Also, the optical amount of startup items is...well, as little as possible. You can always start up what you need when you windows is loaded up. I also don't think choosing Chrome to "startup" is an option to begin with? Startup programs are usually just the ones you find in though task manager. These are usually add-ons to other programs and may act to find and download updates.
You also have some minor alternatives to squeeze some more performance out of your HDD. I usually short-stroke my HDDs to try to minimize the huge drops in access time on a HDD when something is...