Keep ISS enabled. And, I was not referring to the cache ratios in the bios. I was referring to the setting for min and max processor power state in the advanced settings of the power applet in control panel.
I would also NOT disable the C states, unless you are running a PSU that is not Haswell/Intel low power state compatible, and even then, I'd ONLY disable the C6/C7 states. No others.
Once you've determined a stable overclock or if you are running it at the stock clocks, there is no reason not to have Intel speed step enabled. You CAN run a pure "performance" power profile if you like, in the power applet of control panel, but there is no reason you cannot also set the min/max processor power states there to anything between 5% min/100% max. I like to run my chips at 10% minimum processor power state and 100% max. Setting both to 100% is fine though and should not affect sleep settings at all. C states and Intel speed step, will.