If they both have a real-time antivirus component, one of them needs to be disabled or uninstalled, since it's inadvisable to have two or more AV scanners installed at the same time.
https://www.safer-networking.org/faq/live-protection-is-conflicting-with-my-other-av-program/
In all honesty I would ditch Spybot -- it seems to have lost the plot several years ago.