If you are referring to External Gpu Docks, yes there is definitely some bottleneck. The performance will lower by 20-30%. However Gtx1080 is powerful enough to still run games at good 60 fps at 1440p. Sometimes you may have to lower some of your settings down, like using no AA or medium shadows etc. But still Gtx1080 will manage to get good performance even when most of the settings are in Ultra mode.
https://www.youtube.com/watch?v=jFHjT50M7_Y
Edit: I further learned that External Gpu docks have serious bandwidth throttling issues. So anything above 1440p like 4k is a no no.