there are 3 main types of RAM. Unbuffered (Normal RAM) Buffered/Registered/ECC Ram which is just error correcting ram which is mainly used in servers but uses the same time as unbuffered, and FBDIMM or Fully Buffered Dimm which is ONLY found in servers.
Now which one you use depends on what CPU you use.
Most Ryze/Core i CPUS only support Unbuffered or Non-ECC Ram. Xeons then take the ECC/FB DIMM Ram. You have to see what CPU you have and see if it support it. If it is a normal consumer CPU it is more than likely a big No.