Several considerations.
1. PCIe x16 slot
2. PSU wattage
3. Motherboard BIOS
4. Size
1 shouldn't be a problem.
2 is unknown, though I would suspect it will be a problem.
3 is unknown as I'm not familiar with Lenovo's desktops and whether they lock the BIOS (preventing certain upgrades).
4 is something you can check.