Nope, no problem at all. I have one 24" monitor at 180hz and another 23.6" monitor at 60hz both running on my GTX 1080. You'll be fine.
EDIT: I agree with SkyBill, with a 1080Ti, there's no need to game at 1080p. You could be playing AAA titles at 4k, at the minimum, I would use the 1440p for...