1| Don't mix and match rams, they are more harm than good. They will show up probably as a total amount of ram available but in reality they are based off a different batch of silicon(if they are from the same brand) have different internal timings and the last stated point is their mismatched frequency's resulting in degraded performance overall.
2| No matter which config you put it, there is still two sets of rams that operate on two different frequency's. I'd advise on removing the 2x2GB 1333MHz kit from your system and see if all the ram is available for use+you may see a boost in performance.
On that note, might I ask you full systems specs(inclusive of the ram kits sticker specs)? To rule out onboard graphics chip allocating ram...