Yes, even when paired with a Graphics Card the Ryzen CPUs can be limit your maximum FPS with slower RAM. If you're only play at 60 FPS, most titles it'll be fine but if you play games that are CPU heavy or you intend on pushing 75+ FPS, 2133 vs 3000 MHz RAM will start to take a noticeable effect on how high you can go. I've included a benchmark below as an example, almost 10 FPS difference between 2133 & 3000 MHz. Try get a kit from 2800-3200 MHz if you can, it's a great speed area to aim for. Hope this helps!