Question 2GB 1333 + 4GB 1600 vs. 4GB 1600

Sep 4, 2019
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My computer is currently running a DDR3 2GB 1333 ram. I am planning to add/replace it with a DDR3 4GB 1600. Should I set it up with a total of 6GB but runs at 1333 or 4GB that runs at 1600? Also my computer is Acer Aspire M3970.