I am currently using the following.
ASUS TUF GAMING B450M PRO GAMING MOTHERBOARD
SAMSUNG 970 EVO PLUS 500 GB M2 NVME IN 1st M2 slot
HITACHI 500GB HDD IN SATA 1
Bluetooth and wifi card in PCIE 4 slot
RTX 2070 SUPER in the PCIE 16 slot
I bought a 1TB M2 NVME later on and inserted it into the second M2 slot but it was not detected in the bios or windows.
ASUS TUF GAMING B450M PRO GAMING MOTHERBOARD
SAMSUNG 970 EVO PLUS 500 GB M2 NVME IN 1st M2 slot
HITACHI 500GB HDD IN SATA 1
Bluetooth and wifi card in PCIE 4 slot
RTX 2070 SUPER in the PCIE 16 slot
I bought a 1TB M2 NVME later on and inserted it into the second M2 slot but it was not detected in the bios or windows.