[citation][nom]Tindytim[/nom]Not without modification, but there are plenty of guides out there that, with a SNES controller, a USB cable, and a stop at Radio Shack, you can make a USB SNES controller that works great.However, I much prefer using a Dualshock 3 wirelessly for my Emulation needs (NES, SNES, PS1, PS2, etc).[/citation]
I took the original SNES controllers, took out the insides,
then bought a cheap ass USB SNES-a-like controller for PC off of eBay,
taking the insides of the cheap controller, I put those inside the original SNES controller,
Voila!!! USB original SNES controllers.