This software for Asus motherboards creates a virtual drive on a 3 TB HDD that can be used in Windows XP, Vista, and 7.
Asus Software Unlocks HDDs With Over 2.2 TB : Read more
Asus Software Unlocks HDDs With Over 2.2 TB : Read more
The 2.2TB barrier only applies to partitions with MBR.
Windows Vista and 7 can use >2.2TB partitions as long as it is formatted GPT (storage drive, can't boot from it).