I agree with Mark that it's a bit overkill to take your case to the limit on fans. It's more about placement.
Arguments can be made for positive, negative, and neutral pressure setups. All have their merits and have workable designs.
I lean to the middle with neutral pressure, with the GPU fans taken into account, I would agree on the same setup as Mark, two in front, one in back. Try to have at least one of the intakes blowing on the GPUs with as clean a path as possible, and let their fans act as the exhaust for that fan.
The other fan will feed air into the rest of the case, and exhaust through the back.
Your radiator should be on the intake, perhaps with a push-pull config, as the passively cooled parts will tolerate a slightly higher air temp, and your CPU block will be as cool as possible. If the passives start getting too hot, consider moving the radiator to the back so the air isn't being pre-heated, but do expect a slightly warmer CPU. (While the rad is part of the main case flow, you are stuck with this either/or scenario, there's no right answer, just which one works better for you.)
The easy way to check your flow is with a fog machine, if you can get your hands on one. You'll be able to look and see where the dead spots are, and adjust cables/obstructions and fan speeds to reduce them. Don't use smoke, though, and limit the fog used.