No. A clean install implies, at least, selecting the "custom" install over the "upgrade" choice, which basically repartitions and formats the HDD/SSD it's going to be installed on. IMO, it's the only way to properly reinstall the OS.
There are programs that let you play with partitions, but I've never seen an OS successfully separated into its own partition. Do it right the first time. Back up all of your data. Download the latest Win10 installer/Boot USB drive here:
https://www.microsoft.com/en-us/software-download/windows10
If it were me, I'd wipe the drive. Use DBAN (https://dban.org/). Here's how: http://www.techfleece.com/2013/08/22/how-to-securely-wipe-your-hard-drive-using-dban/
DON"T DO THIS TO AN SSD!!!!
Some people will tell you that all you really need to do to your HDD/SSD is to delete the original partition, repartition/reformat it, and then reinstall the OS over it. For complicated reasons (and because I have the time and hardware necessary to wipe a disc--figure 3-4 hours per terabyte) I prefer to wipe before I do a reinstall.
Immediately after the install completes, go to "settings->Update & security->Windows Update->Check for updates" and get all the latest stuff downloaded and installed. When all that is done, load the latest driver for your GPU.
Another argument amongst computeristas: where to put your applications. Most applications want to be on the same disk/partition as the OS. I agree with this, and this is the base assumption that both the OS and the application make. I believe that there is a noticeable speed advantage using this method. Others will say that it all loads in RAM anyway, so what's the big deal? Your choice, although the obvious advantage is to be able to isolate the OS from everything else (although, if you do it this way, you'll find that it isn't really so). Windows (and every other OS in the known universe) will have it's own way, outside of your control, and attempts to isolate the OS, and then reinstall it, are unlikely to succeed.