Windows Defender/Security - that is all I use.
From time to time I have used Malwarebytes to double check if something is amiss.
However, "amiss" is forturnately a rare occurrence simply because, as is often stated in this forum, the best defense is between your ears.
I pay close attention to websites, links to click, etc.. Most being simply garbage clickbait.
Most problems that I encounter are related to User Guide/Manual searches. Especially older devices and components.
Some links that pop up with, for example, "manuals" in the URL - are automatic "no go".
And care is still needed - even if the manufacturer's name is in the pathname that does not mean that the source is the actual manufacturer's website.
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Also, I would be remiss if I did not mention or ask about backups.
You do have all important data backed up at least 2 x to locations away from the host computer.
With the backups proven to be recoverable and readable - correct?
Just my thoughts on the matter.