Interesting cooling design. I was surprised to hear foam space fillers would actually have a significant positive effect on fan performance. Independent laptop graphics cards still carry a heavy premium so upgrading would still be expensive, but the folks for whom this system makes sense would be exactly the people for whom that upgrade cost would make sense. That it can fit any new 2011 socket processors, and fit them within the thermal spec as well, definitely does open up CPU upgrade possibilities.
This could fit as business workhorse for rapid rendering in remote or highly mobile work settings. Imagine rendering building architecture and running modelling on a major build work site, where you're changing base every so often, up the building as the work progresses, and packing up after that particular project is complete. It could also allow professional musicians quality portable digital recording and encoding, if the input is as quality as the headphone output, at the location of any concert they happen to take it to.