I used the amount required to give full coverage of the surface for each for the thermal transfer, but not an excessive amount where it pools over the sides. Per DC support this was to be used on the 'short' registers surrounding the GPU as well as the 'tall' registers on the right side of the card. The heatsinks with this adhesive could not be twisted off, nor would rubbing alcohol disolve the bond even for the heatsinks that I could remove (used a fingernail, an eraser, and an excessive amount of time). All of the heatsinks were difficult to remove, but the ones on the tall registers had a stronger adhesion than the solder of the register to the board - and yes I was being VERY careful in the attempt to remove them. And yes there were pictures sent to DC documenting the issue of the cooler not fitting and the damage that occured.