Update your post to include full system hardware specs and OS.
GPU, PSU, etc.. Make and model information.
PSU: make, model, wattage, age, condition? Heavy gaming use?
What game(s) are affected?
Did you try reinstalling the mouse drivers?
You can also try the built in Windows Troubleshooters. The troubleshooters may find and fix something.
Also "sfc /scannow" and "dism" may fix some file corruption problem.
https://www.howtogeek.com/222532/ho...-system-files-with-the-sfc-and-dism-commands/
In Resource Monitor focus on the CPU and the "Description" column and the Average CPU. (Remember you can click those very small arrows the column headers to do some sorting in the presentation.
Likewise in Task Manager look at the processes that are running. You can click the CPU column header there as will to sort %'s
Objective is to determine if something "mouse" related is consuming the CPU resource. Or possibly something else that is running and causing a conflict.