Yesterday, when I saw Fractal Design's showcase video for the Define Nano S my first thought was this is in response to the Phanteks Enthoo Evolv ITX as direct competition. So I did a scale image comparison between the Evolv ITX and the Nano S by overlaying rear view photos of both lining up the PSU mounting screw holes. I wanted to see which case had more GPU breathing room. The Nano S has less space between a 2-slot GPU and the PSU then the Evolv ITX has. Bear in mind that the Evolv ITX has a PSU shroud in between, but it's also heavily perforated with holes. For non-reference multi-fan cooler GPUs this GPU/PSU breathing room gap may make a difference, I don't know?