I haven't had any issues with one card, however, I have problems with crossfire in BF4. While in 64 player maps, I get frame stuttering and lower FPS than in less populated maps. I've noticed my FX 8350 almost maxing out all eight cores but my two R9 280X's only hitting 60-70% usage. With only one card my cores don't break a sweat but my card will run at 99-100%. It will even run both cards at max in other games. So to answer your question; no.
AMD FX 8350
Asus M5A 99FX PRO R2.0
16GB G Skill 1866
Samsung 840 250GB
2x Asus R9 280x in crossfire
Corsair H80i
Cooler Master V1000 PSU
Cooler Master HAF X