Gigabyte GA B85M-D3H-A

Solution
It can't support SLI; the specs don't even meet the requirements. It will have no problems supporting a single GPU; Crossfire support is provided, but at 4x it isn't good enough for high-end AMD GPUs.
Actually it depends on your budget and needs. But long answer short yes.. absolutely yes. It will support most of the cards and you can even SLI if you want. Just make sure to get a good quality PSU. 😉

Update: Okay I am sorry I didn't meant SLI... I meant AMD CROSSFIRE. I actually gets confused and type them wrongly.(not typing mistake but concentration mistake 😛 ).
 
It can't support SLI; the specs don't even meet the requirements. It will have no problems supporting a single GPU; Crossfire support is provided, but at 4x it isn't good enough for high-end AMD GPUs.
 
Solution
Okay.. Sorry. I know what you meant. I actually typed it by mistake. I meant CROSSFIRE. Its not a typing mistake.. I actually was talking about SLI with someone and accidentally typed it here. SORRY AGAIN! 🙁