Not really sure what your question is.
I run a 980 ti at 2560 x 1440 on a 144hz monitor at Ultra for almost all my games. I sacrifice fps because I place a high value on how a game looks, but my games don't drop below 60 fps.
If you want to know what settings are going to get you 144 frames, then I'd be inclined to say that medium is your best bet.