Hello. This maybe an old thread, yet, it is still one of the stop search results. So I will post my fix for a similar problem. My issue was that I kept getting permission errors when installing software and video games on my secondary internal hard drive "Program files folder". The fix was quite easy, although there is a little catch.
Right click hard drive ->Security tab-> Click "edit" to change permissions.
Now look to see if your user name is listed. If it is not, that is your problem. If it is, check to see what permissions that have been checked. I usually just click "full control" and be done with it.
If your user name is not listed then click Add -> Advanced -> then search for your user name by clicking "find now"; highlight your user name ->click okay; check "full control" under permissions then hit Apply.
The catch was I could not add permissions for my "programs files" folder but I could add permissions for folders within the "programs files" folder. Freaky I know. But the steps above helped me install the program.