"worth" is something only YOU can determine.
Generally, though, you will not notice a fast nvme pcie drive as noticeably faster than a conventional sata drive.
Perhaps in something like a virus scan.
OTOH, if you have the funds, why not buy a pcie m.2 drive, they do not cost all that much more.
As to the fastest m.2 device, that would be one of the Intel OPTANE device.
The big benefit is latency that is an order of magnitude better.
Most ssd activity is small low queue depth random I/O
https://hothardware.com/reviews/intel-optane-ssd-800p-review