Alot of what you "might should" do will depend on your approach to o'clocking - especially when considering if you are going to add waterblocks for things like the northbridge or southbridge. I actually think that a sounthbridge waterblock is not necessary under any conditions really as the southbridge pretty much just deals with the raid/IDE/SATA aspects and while it may generate some heat, it will never be so much that a good heatsink and proper airflow in your case can't handle.
The only reason to add a northbridge waterblock, really, is if you aggressively o'clock. I mean, if you o'clock your CPU, GPU's, RAM and adjust your votages. The Northbridge, typically, controls memory functions like – a memory controller (for Intel Chipsets), a level 2 cache communicator and bridges the gap between the CPU and Ram – it also handles functions between the CPU and the graphics processor on the PCI, AGP and PCIe slots. Since this particular part is always busy it can generate quite a lot of heat. If you mildly o'clock than a decent HSF combo, some good cable management and airflow would suffice.
Now, if you don't o'clock at all than you could get by with a single rad - but, iun a two PCB video setup and a CPU - that rad needs to be a triple 120mm. Now, if you do any sort of o'clocking - even mildly - than you should consider that, in a single rad cooling solution, some components are going to have to deal with the heat they generate and the heat from the other components. So, if your CPU is first in line than the heat from it will compound with the heat from the first gpu. The second GPU will then have to deal with the heat from the CPU and the GPU before it. So, in this scenario you might consider a dual rad setup where the CPU gets one rad and the other is reserved for the dual PCB video configuration.