The Clean install will wipe the contents of the C: drive
So any data files you want to keep need to be backed up or stored on D: or other drive letter or over the network in the Cloud etc
Sometimes it is possible to change motherboard without a clean install,
(though it is not recomended unless motherboard is similar to old one eg same chipset)
(backup in data case things go wrong)
uninstall drivers from control panel Programs
such as audio, network, graphics card (if using build in graphics)
remove hard disk controller driver from registry
using tools such as Fix HDC found in Hirens Boot CD
Then shut down windows and change motherboard
This assumes you have a retail copy of Win 10 or you upgraded a retail copy of older Windows 7 or 8 or 8.1
OEM Windows versions do not allow motherboard upgrades.
regards
Mike Barnes