It's not impossible. How easy or difficult it is depends on the complexity of the parts you are going to use. The more high-end and high-performance the parts, often the build also gets tougher. But the most part of building a PC is just putting everything where it has to go and tightening some screws. It's really not that difficult. Choosing parts can be harder than building the PC sometimes.
As for tips, of course I'd suggest watching a few PC building guides(not the one from Verge, please) - watch the full video, see where everything goes. Try to find a video with similar parts to what you plan on getting. If you get into any trouble you can always ask here to be sure. Take care about the ESD thing - touch a grounded piece of metal...